PEDIATRICS Vol. 79 No. 6 June 1987, pp. 922-927
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brunell, P. A.
Right arrow Articles by Narkewicz, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunell, P. A.
Right arrow Articles by Narkewicz, S.

Varicella-Like Illness Caused by Live Varicella Vaccine in Children With Acute Lymphocytic Leukemia

Philip A. Brunell MD1, Clementina F. Geiser MD1, Valerio Novelli MD1, Susan Lipton MD1, and Sarah Narkewicz RN, MS1

1 From the Department of Pediatrics, The University of Texas Health Science Center, San Antonio

A varicella-like illness occurred in five of 52 children with acute lymphocytic leukemia following the administration of live varicella vaccine. Only one of the children required treatment with acyclovir. Virus isolated from two of the children was "vaccine-like" but differed slightly from the original vaccine strain when tested by restriction enzyme analysis. There did not appear to be a reversion to virulence because two of the household contacts who seroconverted had mild or subclinical infections. Vaccinees in whom this reaction developed tended to have a poor cellular immune response to varicellazoster virus.

Key Words: varicella vaccine • leukemia • vesicular rash • restriction enzyme • cell-mediated immunity

Submitted on May 1, 1986
Accepted on July 11, 1986




This article has been cited by other articles:


Home page
 PediatricsHome page
P. Jean-Philippe, A. Freedman, M. W. Chang, S. P. Steinberg, A. A. Gershon, P. S. LaRussa, and W. Borkowsky
Severe Varicella Caused by Varicella-Vaccine Strain in a Child With Significant T-Cell Dysfunction
Pediatrics, November 1, 2007; 120(5): e1345 - e1349.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. I. Cohen, P. A. Brunell, S. E. Straus, and P. R. Krause
Recent Advances in Varicella-Zoster Virus Infection
Ann Intern Med, June 1, 1999; 130(11): 922 - 932.
[Abstract] [Full Text] [PDF]

Home page
 JWatch GeneralHome page
LIVE VARICELLA VACCINE IN CHILDREN WITH LEUKEMIA
Journal Watch (General), July 17, 1987; 1987(717): 32 - 32.
[Full Text]