PEDIATRICS Vol. 79 No. 5 May 1987, pp. 837-838
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Smokeless Tobacco and Hypertension in an Adolescent

RAYMOND D. ADELMAN MD1

1 Department of Pediatrics, Division of Pediatric Nephrology, University of California, Davis, 4301 X St, Sacramento, CA 95817

To the Editor.—

Concern has been expressed recently about the health hazards of the widespread use of smokeless tobacco by

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children. Some surveys have reported regular use by as many as 12% to 33% of male high school students.1,2 Complications of smokeless tobacco include oral cancer, periodontal disease, and dependence. Hypertension may also occur due to the sodium and nicotine content of smokeless tobacco1 and glycyrrhizinic acid. This extract of Glycyrrhiza glabra root, present in many chewing tobaccos and natural licorice, has potent mineralocorticoid activity and may produce hypertension and, in some patients, hypokalemia, alkalosis, sodium and water retention, and suppressed plasma renin activity.3-5




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P. N Lee
Circulatory disease and smokeless tobacco in Western populations: a review of the evidence
Int. J. Epidemiol., August 1, 2007; 36(4): 789 - 804.
[Abstract] [Full Text] [PDF]