PEDIATRICS Vol. 79 No. 4 April 1987, pp. 593-597
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Comparison of Self-Hypnosis and Propranolol in the Treatment of Juvenile Classic Migraine

Karen Olness MD1, John T. MacDonald MD1, and Donald L. Uden PharmD1

1 The Departments of Pediatric Neurology, Behavioral Pediatrics and Research, and Pharmacy, Minneapolis Children's Medical Center, Minneapolis

In a prospective study we compared propranolol, placebo, and self-hypnosis in the treatment of juvenile classic migraine. Children aged 6 to 12 years with classic migraine who had no previous specific treatment were randomized into propranolol (at 3 mg/kg/d) or placebo groups for a 3-month period and then crossed over for 3 months. After this 6-month period, each child was taught self-hypnosis and used it for 3 months. Twenty-eight patients completed the entire study. The mean number of headaches per child for 3 months during the placebo period was 13.3 compared with 14.9 during the propranolol period and 5.8 during the self-hypnosis period. Statistical analysis showed a significant association between decrease in headache frequency and self-hypnosis training (P = .045). There was no significant change in subjective or objective measures of headache severity with either therapy.

Key Words: migraine • propranolol • self-hypnosis • pain

Submitted on March 7, 1986
Accepted on May 13, 1986




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