PEDIATRICS Vol. 79 No. 4 April 1987, pp. 553-558
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Binding Effect of Albumin on Uptake of Bilirubin by Brain

P. J. Robinson PhD1 and S. I. Rapoport MD1

1 The Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland

A mathematical model is presented to describe quantitatively the uptake of bilirubin into the brain from blood, under conditions of extensive binding to plasma proteins. The model relates bilirubin uptake to the rate constants for dissociation and association of the albumin/bilirubin complex and to the transit time of blood through brain capillaries. A rational basis is given for deciding between the total or the free bilirubin concentration as an appropriate indicator of brain exposure to the toxic effects of bilirubin. The effect of competition for binding sites by drugs such as sulfonamides on the brain uptake of bilirubin is also described quantitatively.

Key Words: protein binding • kernicterus • blood-brain barrier • mathematical modeling • sulfonamide • hyperbilirubinemia

Accepted on June 25, 1986




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