PEDIATRICS Vol. 79 No. 3 March 1987, pp. 434-436
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Hypertrichosis and Congenital Anomalies Associated With Maternal Use of Minoxidil

STEPHEN G. KALER MD1, MARY ELAINE PATRINOS MD1, GEORGE H. LAMBERT MD1, THOMAS F. MYERS MD1, ROBERTA KARLMAN MD1, and CRAIG L. ANDERSON MD1

1 Department of Pediatrics and the Division of Newborn Medicine and the Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL

Minoxidil is a potent peripheral vasodilating agent used in the treatment of severe hypertension refractory to more conventional therapy. Its use in pregnant women and its effect on pregnancy outcome have not previously received attention in the medical literature.

Hypertrichosis is a well-known side effect of minoxidil.1 It occurs in nearly all patients treated for longer than 4 weeks and is reversible after discontinuation of the drug.2

We recently observed hypertrichosis and multiple congenital anomalies in an infant whose mother was on a regimen of minoxidil, as well as captopril and propranolol, continuously throughout pregnancy As the importance of case reporting in instances of possible teratogenicity has recently been underscored,3 we wish to describe our findings and to encourage additional reports of pregnancy outcome after maternal use of minoxidil.

Submitted on June 11, 1986
Accepted on August 22, 1986