PEDIATRICS Vol. 79 No. 2 February 1987, pp. 314-315
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Neonatal Intracranial Hemorrhage and Phenobarbital

O. G. BATTISTI MD1, J. M. BERTRAND MD1, and J. P. LANGHENDRIES MD1

1 Neonatal Intensive Care Unit, Clinique St-Vincent, Rocourt-Liége, Belgium

To the Editor.—

We appreciate the recent study by Kuban et al1 about neonatal intracranial hemorrhage and phenobarbital use, but we would like to mention several points.

The number of neonates not having been enrolled represents a high proportion of the eligible population (263/554 or 47.5%) from which 48 (8.7%) had hemorrhage before enrollment, suggesting that the inclusion criteria were not sufficient according to the pathophysiology of cerebral blood flow variability in the neonates. In fact, the authors were missing 48/140 (34.3%) of infants with any hemorrhage (the number of infants with any hemorrhage they studied was 92).