PEDIATRICS Vol. 79 No. 2 February 1987, pp. 281-282
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Liver Injury After Oral and Rectal Administration of N-Acetylcysteine for Meconium Ileus Equivalent in a Patient With Cystic Fibrosis

DAVID J. BAILEY MD1 and JOEL M. ANDRES MD1

1 University of Florida, College of Medicine, Gainesville

N-acetylcysteine (NAC) is a mucolytic agent (Mucomyst, Mead-Johnson) that is often used for the treatment of meconium ileus equivalent, a complication of cystic fibrosis.1-3 No serious adverse reactions to nonparenterally administered NAC have been observed, and there have been no reports of significant hepatotoxicity. We describe a patient in whom severe hepatic dysfunction occurred on two occasions after the administration of NAC for the treatment of meconium ileus equivalent.

CASE REPORT

A 3-year-old, 12.5-kg, white boy with cystic fibrosis was admitted for treatment of a fractured left femur. His medications included theophylline, metaproterenol, cefaclor, nebulized isoethanine, and pancreatic enzyme replacement with meals.

Submitted on January 17, 1986
Accepted on May 1, 1986




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