PEDIATRICS Vol. 79 No. 1 January 1987, pp. 99-102
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Pulmonary Vascular Lipid Deposition After Administration of Intravenous Fat to Infants

Robert J. Shulman MD1, Claire Langston MD1, and Richard J. Schanler MD1

1 From the US Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center and Departments of Pediatrics and Pathology, Baylor College of Medicine and Texas Children's Hospital, Houston

The incidence of pulmonary vascular lipid deposits in infants who did or did not receive intravenous lipid emulsion was determined through a review of the pulmonary histopathology and clinical course of 39 neonates who died during a two-year period. The relationship between pulmonary vascular lipid deposits and the duration and amount of administered intravenous fat emulsion was assessed. In addition, the effect of monitored serum triglyceride levels on the development of pulmonary vascular lipid deposits was evaluated. The incidence of pulmonary vascular lipid deposits was greater in the group that received intravenous fat emulsion (P < .02). Both the amount (grams per kilogram per day) and duration (days) of intravenous fat emulsion infusion were correlated positively with severity (P < .05) in infants who had pulmonary vascular lipid deposits. No relationship was seen between peak serum triglyceride levels, the frequency of elevated triglycerides, and pulmonary vascular lipid deposits. Although administered fat emulsion was a risk factor for the development of pulmonary vascular deposits, two of 13 infants who had not received intravenous fat emulsion had such deposits.

Key Words: pulmonary lipid deposition • intravenous fat • elevated triglyceride level

Submitted on August 26, 1985
Accepted on April 10, 1986




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