PEDIATRICS Vol. 79 No. 1 January 1987, pp. 26-30
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Is Chronic Lung Disease in Low Birth Weight Infants Preventable? A Survey of Eight Centers

Mary Ellen Avery MD1, William H. Tooley MD1, Jacob B. Keller MPH1, Suzanne S. Hurd PhD1, M. Heather Bryan MD1, Robert B. Cotton MD1, Michael F. Epstein MD1, Pamela M. Fitzhardinge MD1, Cheryl B. Hansen RN1, Thomas N. Hansen MD1, W. Alan Hodson MD1, L. Stanley James MD1, Joseph A. Kitterman MD1, Heber C. Nielsen MD1, Theresa A. Poirier RN1, William E. Truog MD1, and Jen-Tien Wung MD1

1 From Brigham and Women's Hospital, Boston; University of California, San Francisco; National Heart, Lung, and Blood Institute, Bethesda; Mt Sinai Hospital, Toronto; Vanderbilt University, Nashville, TN; Baylor University, Houston; University of Washington, Seattle; Columbia Presbyterian Medical Center, New York; and Southwestern Medical School, Dallas

Chronic lung disease in prematurely born infants, defined as the need for increased inspired oxygen at 28 days of age, was thought to be more common in some institutions than in others. To test this hypothesis, we surveyed the experience in the intensive care nurseries at Columbia and Vanderbilt Universities, the Universities of Texas at Dallas, Washington at Seattle, and California at San Francisco, the Brigham and Women's Hospital in Boston, Texas Children's Hospital in Houston, and Mt Sinai Hospital in Toronto. The survey included 1,625 infants with birth weights of 700 to 1,500 g. We confirmed the relationship of risk to low birth weight, white race, and male sex. Significant differences in the incidence of chronic lung disease were found between institutions even when birth weight, race, and sex were taken into consideration through a multivariate logistic regression analysis. Columbia had one of the best outcomes for low birth weight infants and the lowest incidence of chronic lung disease.

Key Words: bronchopulmonary dysplasia • premature infant • mechanical ventilation

Submitted on June 9, 1986




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