PEDIATRICS Vol. 79 No. 1 January 1987, pp. 26-30
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Is Chronic Lung Disease in Low Birth Weight Infants Preventable? A Survey of Eight Centers

Mary Ellen Avery MD1, William H. Tooley MD1, Jacob B. Keller MPH1, Suzanne S. Hurd PhD1, M. Heather Bryan MD1, Robert B. Cotton MD1, Michael F. Epstein MD1, Pamela M. Fitzhardinge MD1, Cheryl B. Hansen RN1, Thomas N. Hansen MD1, W. Alan Hodson MD1, L. Stanley James MD1, Joseph A. Kitterman MD1, Heber C. Nielsen MD1, Theresa A. Poirier RN1, William E. Truog MD1, and Jen-Tien Wung MD1

1 From Brigham and Women's Hospital, Boston; University of California, San Francisco; National Heart, Lung, and Blood Institute, Bethesda; Mt Sinai Hospital, Toronto; Vanderbilt University, Nashville, TN; Baylor University, Houston; University of Washington, Seattle; Columbia Presbyterian Medical Center, New York; and Southwestern Medical School, Dallas

Chronic lung disease in prematurely born infants, defined as the need for increased inspired oxygen at 28 days of age, was thought to be more common in some institutions than in others. To test this hypothesis, we surveyed the experience in the intensive care nurseries at Columbia and Vanderbilt Universities, the Universities of Texas at Dallas, Washington at Seattle, and California at San Francisco, the Brigham and Women's Hospital in Boston, Texas Children's Hospital in Houston, and Mt Sinai Hospital in Toronto. The survey included 1,625 infants with birth weights of 700 to 1,500 g. We confirmed the relationship of risk to low birth weight, white race, and male sex. Significant differences in the incidence of chronic lung disease were found between institutions even when birth weight, race, and sex were taken into consideration through a multivariate logistic regression analysis. Columbia had one of the best outcomes for low birth weight infants and the lowest incidence of chronic lung disease.

Key Words: bronchopulmonary dysplasia • premature infant • mechanical ventilation

Submitted on June 9, 1986


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T. E. Young, L. S. Kruyer, D. D. Marshall, C. L. Bose, and the North Carolina Neonatologists Association
Population-based Study of Chronic Lung Disease in Very Low Birth Weight Infants in North Carolina in 1994 With Comparisons With 1984
Pediatrics, August 1, 1999; 104(2): 17e - 17.
[Abstract] [Full Text]


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PediatricsHome page
W. Lindner, S. Voßbeck, H. Hummler, and F. Pohlandt
Delivery Room Management of Extremely Low Birth Weight Infants: Spontaneous Breathing or Intubation?
Pediatrics, May 1, 1999; 103(5): 961 - 967.
[Abstract] [Full Text]


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CirculationHome page
J. Kattwinkel, S. Niermeyer, V. Nadkarni, J. Tibballs, B. Phillips, D. Zideman, P. Van Reempts, and M. Osmond
ILCOR Advisory Statement: Resuscitation of the Newly Born Infant : An Advisory Statement From the Pediatric Working Group of the International Liaison Committee on Resuscitation
Circulation, April 13, 1999; 99(14): 1927 - 1938.
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PediatricsHome page
L. Charafeddine, C. T. D'Angio, and D. L. Phelps
Atypical Chronic Lung Disease Patterns in Neonates
Pediatrics, April 1, 1999; 103(4): 759 - 765.
[Abstract] [Full Text]


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PediatricsHome page
J. Kattwinkel, S. Niermeyer, V. Nadkarni, J. Tibballs, B. Phillips, D. Zideman, P. Van Reempts, and M. Osmond
An Advisory Statement From the Pediatric Working Group of the International Liaison Committee on Resuscitation
Pediatrics, April 1, 1999; 103(4): 56e - 56.
[Abstract] [Full Text]


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Pediatr. Rev.Home page
J. F. Hansbrough and W. Hansbrough
Pediatric Burns
Pediatr. Rev., April 1, 1999; 20(4): 117 - 124.
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Am. J. Respir. Crit. Care Med.Home page
K. H. ALBERTINE, G. P. JONES, B. C. STARCHER, J. F. BOHNSACK, P. L. DAVIS, S.-C. CHO, D. P. CARLTON, and R. D. BLAND
Chronic Lung Injury in Preterm Lambs . Disordered Respiratory Tract Development
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 945 - 958.
[Abstract] [Full Text]


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PediatricsHome page
H. Verder, P. Albertsen, F. Ebbesen, G. Greisen, B. Robertson, A. Bertelsen, L. Agertoft, B. Djernes, E. Nathan, and J. Reinholdt
Nasal Continuous Positive Airway Pressure and Early Surfactant Therapy for Respiratory Distress Syndrome in Newborns of Less Than 30 Weeks' Gestation
Pediatrics, February 1, 1999; 103(2): 24e - 24.
[Abstract] [Full Text]


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PediatricsHome page
D. K. Richardson, J. E. Gray, S. L. Gortmaker, D. A. Goldmann, D. M. Pursley, and M. C. McCormick
Declining Severity Adjusted Mortality: Evidence of Improving Neonatal Intensive Care
Pediatrics, October 1, 1998; 102(4): 893 - 899.
[Abstract] [Full Text] [PDF]


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PediatricsHome page
P. L. Ramsay, E. O'Brian Smith, S. Hegemier, and S. E. Welty
Early Clinical Markers for the Development of Bronchopulmonary Dysplasia: Soluble E-Selectin and ICAM-1
Pediatrics, October 1, 1998; 102(4): 927 - 932.
[Abstract] [Full Text] [PDF]


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Arch. Dis. Child. Fetal Neonatal Ed.Home page
N J Robertson and P A Hamilton
Randomised trial of elective continuous positive airway pressure (CPAP) compared with rescue CPAP after extubation
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1998; 79(1): 58F - 60.
[Abstract] [Full Text]


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Arch. Dis. Child. Fetal Neonatal Ed.Home page
M. van der Hoeven, E. Brouwer, and C. E Blanco
Nasal high frequency ventilation in neonates with moderate respiratory insufficiency
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1998; 79(1): 61F - 63.
[Abstract] [Full Text]


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PediatricsHome page
H. J. Rozycki, G. D. Sysyn, M. K. Marshall, R. Malloy, and T. E. Wiswell
Mainstream End-tidal Carbon Dioxide Monitoring in the Neonatal Intensive Care Unit
Pediatrics, April 1, 1998; 101(4): 648 - 653.
[Abstract] [Full Text] [PDF]


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Arch. Dis. Child. Fetal Neonatal Ed.Home page
A SMEDSAAS-LÖFVENBERG, G FAXELIUS, I AXELSSON, and H LAGERCRANTZ
Nasal deformities at a UK hospital
Arch. Dis. Child. Fetal Neonatal Ed., March 1, 1998; 78(2): 156F - 156.
[Full Text]


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Am. J. Respir. Crit. Care Med.Home page
J Stocks, M Henschen, A. Hoo, K Costeloe, and C Dezateux
Influence of ethnicity and gender on airway function in preterm infants
Am. J. Respir. Crit. Care Med., December 1, 1997; 156(6): 1855 - 1862.
[Abstract] [Full Text]


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PediatricsHome page
L. Singer, T. Yamashita, L. Lilien, M. Collin, and J. Baley
A Longitudinal Study of Developmental Outcome of Infants With Bronchopulmonary Dysplasia and Very Low Birth Weight
Pediatrics, December 1, 1997; 100(6): 987 - 993.
[Abstract] [Full Text] [PDF]


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Arch. Dis. Child. Fetal Neonatal Ed.Home page
B.-H. Su, T. Watanabe, M. Shimizu, and M. Yanagisawa
Doppler assessment of pulmonary artery pressure in neonates at risk of chronic lung disease
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 1997; 77(1): 23F - 27.
[Abstract] [Full Text]


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PediatricsHome page
M. C. McCormick
The Outcomes of Very Low Birth Weight Infants: Are We Asking the Right Questions?
Pediatrics, June 1, 1997; 99(6): 869 - 869.
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PediatricsHome page
J. D. Horbar, G. J. Badger, E. M. Lewit, J. Rogowski, and P. H. Shiono
Hospital and Patient Characteristics Associated With Variation in 28-Day Mortality Rates for Very Low Birth Weight Infants
Pediatrics, February 1, 1997; 99(2): 149 - 156.
[Abstract] [Full Text] [PDF]


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CLIN PEDIATRHome page
B. E. Fleisher, K. VandenBerg, J. Constantinou, C. Heller, W. E. Benitz, A. Johnson, A. Rosenthal, and D. K. Stevenson
Individualized Developmental Care for Very-Low-Birth-Weight Premature Infants
Clinical Pediatrics, October 1, 1995; 34(10): 523 - 529.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
A. H. Jobe
Hypocarbia and Bronchopulmonary Dysplasia
Arch Pediatr Adolesc Med, June 1, 1995; 149(6): 615 - 616.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
J. S. Garland, R. K. Buck, E. N. Allred, and A. Leviton
Hypocarbia Before Surfactant Therapy Appears to Increase Bronchopulmonary Dysplasia Risk in Infants With Respiratory Distress Syndrome
Arch Pediatr Adolesc Med, June 1, 1995; 149(6): 617 - 622.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
C. A. Patel and J. M. Klein
Outcome of Infants With Birth Weights Less Than 1000 g With Respiratory Distress Syndrome Treated With High-Frequency Ventilation and Surfactant Replacement Therapy
Arch Pediatr Adolesc Med, March 1, 1995; 149(3): 317 - 321.
[Abstract] [PDF]


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NEJMHome page
H. Verder, B. Robertson, G. Greisen, F. Ebbesen, P. Albertsen, K. Lundstrom, T. Jacobsen, and The Danish-Swedish Multicenter Study Group
Surfactant Therapy and Nasal Continuous Positive Airway Pressure for Newborns with Respiratory Distress Syndrome
N. Engl. J. Med., October 20, 1994; 331(16): 1051 - 1055.
[Abstract] [Full Text]


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CLIN PEDIATRHome page
S. J. Bachrach, F. S. Pidcock, P. A. Branca, P. L. Gilbert, A. Schneider, L. Walko, and B. McHugh
Early Transfer to a Rehabilitation Hospital For Infants With Chronic Bronchopulmonary Dysplasia
Clinical Pediatrics, September 1, 1993; 32(9): 535 - 541.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
S. Davidson, A. Schrayer, E. Wielunsky, R. Krikler, P. Lilos, and S. H. Reisner
Energy Intake, Growth, and Development in Ventilated Very-Low-Birth-Weight Infants With and Without Bronchopulmonary Dysplasia
Arch Pediatr Adolesc Med, May 1, 1990; 144(5): 553 - 559.
[Abstract] [PDF]


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JAMAHome page
M. C. McCormick
Long-term Follow-up of Infants Discharged From Neonatal Intensive Care Units
JAMA, March 24, 1989; 261(12): 1767 - 1772.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
R. L. Gibson, J. C. Jackson, G. A. Twiggs, G. J. Redding, and W. E. Truog
Bronchopulmonary Dysplasia: Survival After Prolonged Mechanical Ventilation
Arch Pediatr Adolesc Med, July 1, 1988; 142(7): 721 - 725.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
A. C. MOESSINGER
Chronic Lung Disease in Children Born With Sublethal Lung Hypoplasia
Arch Pediatr Adolesc Med, May 1, 1988; 142(5): 484 - 484.
[Abstract] [PDF]


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Arch Pediatr Adolesc MedHome page
W. F. POWERS and P. D. HEGWOOD
Chronic Lung Disease in VLBW Infants
Arch Pediatr Adolesc Med, May 1, 1988; 142(5): 484 - 485.
[Abstract] [PDF]