PEDIATRICS Vol. 78 No. 5 November 1986, pp. 954-955
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Cranial Bruising and Intraventricular Hemorrhage

KARL C. K. KUBAN MD1, ELIZABETH BROWN MD1, ALAN LEVITON MD1, and KALPATHY KRISHNAMOORTHY MD1

1 Department of Neurology, The Children's Hospital, 300 Longwood Ave., Boston, MA 02115

In Reply.—

The letter of Acs and Kilchevsky gives us an opportunity to reemphasize that our study was designed to evaluate the efficacy of phenobarital as prophylaxis for intracranial hemorrhage of the premature newborn. To this end, we defined possible confounders as those variables associated with both hemorrhage and phenobarbital administration. The observation of Acs and Kilchevsky that cranial bruising occurred more often in the phenobarbital-treated group and in the babies with intracranial hemorrhage is indeed important.