PEDIATRICS Vol. 78 No. 4 October 1986, pp. 748-756
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Varicella Vaccine Studies in Healthy Children and Adults

Allan M. Arbeter MD1, Stuart E. Starr MD1, and Stanley A. Plotkin MD1

1 From the Department of Pediatrics, Albert Einstein Medical Center—Northern and Temple University School of Medicine and The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia

Immunization of normal children and adults with Oka strain live varicella vaccine from several manufacturers has been studied in our laboratory and elsewhere. This paper summarizes clinical trials designed to obtain information on minimum dose immunogenicity pre- and postexposure prophylaxis, immunization of various age groups, and booster immunizations for seropositive individuals. These studies documented a 94% to 100% seroconversion rate with 95% to 100% persistence of antibodies at 3 to 4 years. Protective efficacy was more than 90%, and the vaccine was successful in preventing varicella when a high dose was given postexposure. Clinical reactions were limited to temperature elevations and minor papulovesiculan rashes that occurred in 5% to 10% of vaccinees. Herpes zoster has been absent in vaccinated healthy individuals.




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