PEDIATRICS Vol. 78 No. 3 September 1986, pp. 547-548
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Persistent Colonization During Therapy for MHaemophilus influenzae Type b Disease

LESLIE L. BARTON MD1

1 Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, St Louis, MO 63104

To the Editor.—

Dr Gilsdorf's rather reassuring recommendation to discontinue respiratory isolation for children with Haemophilus influenzae type b infections after 24 hours of parenteral therapy, "without increased risk of nosocomial infection," was based on her failure to show nasopharyngeal colonization with H influenzae type b after 24 hours of appropriate antibiotics.1 Although this is in accord with currently recommended isolation policies, a modicum of skepticism should remain.

Previous studies have demonstrated the persistence of H influenzae type b in the nasopharynx and throat for up to six days after parenteral antibiotic therapy.2,3