PEDIATRICS Vol. 78 No. 3 September 1986, pp. 547
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Virilizing Adrenocortical Tumors in Childhood

J. W. HONOUR PHD1, D. A. PRICE MA, FRCP2, and D. B. GRANT MD, FRCP3

1 Cobbold Laboratories, Middlesex Hospital, Mortimer St, London
2 Royal Manchester Childrens Hospital, Pendlebury, Manchester, England
3 Hospital for Sick Children, Great Ormond St, London

To the Editor.—

It was of considerable interest to read about the experience of virilizing adrenal tumors at the Childrens Memorial Hospital, Chicago,1 and the literature review is of particular value. In 1984, we published results from our study during 12 years of 12 infants with virilizing adrenal tumors without cortisol excess. We were able to define very precisely the secretory products of the tumors by using capillary column gas chromatography with mass spectrometry to separate and identify steroids in urine, and the data were rationalized in the context of routine endocrine tests.