PEDIATRICS Vol. 78 No. 3 September 1986, pp. 514-515
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Severe Reactivation of Sunburn Following Methotrexate Use

SUSAN B. MALLORY MD1 and D. H. BERRY MD1

1 Departments of Dermatology and Pediatrics, University of Arkansas for Medical Sciences, Little Rock

Methotrexate is not an infrequently used drug in chemotherapy protocols. The following, however, is an uncommon side effect of this medication.

CASE REPORT

A 13-year-old white boy was diagnosed as having non-Hodgkin's lymphoma by lymph node biopsy 2 years prior to the onset of his dermatitis. While on a fishing trip in May 1984, a mild sunburn developed after 1frac12 hours in the sun. Two days later, his sunburn was barely noticeable. He underwent chemotherapy which included highdose intravenous methotrexate with leucovorin rescue, as well as intrathecal methotrexate, cytarabine, and hydrocortisone. Shortly after the injection of intravenous methotrexate, he noted tingling and burning at the sites of his resolving sunburn.




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G P Thami, S Kaur, and A J Kanwar
Delayed reactivation of haloperidol induced photosensitive dermatitis by methotrexate
Postgrad. Med. J., February 1, 2002; 78(916): 116 - 117.
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