PEDIATRICS Vol. 78 No. 3 September 1986, pp. 473-479
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Constipation and Meconium Ileus Equivalent in Patients With Cystic Fibrosis

Steven Rubinstein MD1, Richard Moss MD1, and Norman Lewiston MD1

1 From the Division of Allergy and Pulmonary Diseases, Department of Pediatrics, Children's Hospital at Stanford and Stanford University Hospital, Palo Alto, California

Constipation and its complications, particularly meconium ileus equivalent, may become management problems in patients with cystic fibrosis. The medical records of 168 patients with cystic fibrosis were reviewed for the prevalence of constipation and meconium ileus equivalent. Of 168 patients, 54 (32%) had experienced at least one episode of constipation which responded to oral or rectal laxative therapy. In 16 of the study group (9%) meconium ileus equivalent developed. Patients younger than 5 years of age had a lower prevalence and those older than 30 years of age had a much higher prevalence of both conditions. Those with prolonged histories of inadequately controlled steatorrhea appeared to be at higher risk for the eventual development of meconium ileus equivalent. Recurrences and complications of constipation may be avoided by instituting early and aggressive therapy.

Key Words: cystic fibrosis • constipation • intestinal obstruction • meconium ileus equivalent • laxative

Submitted on June 28, 1985
Accepted on November 15, 1985




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