PEDIATRICS Vol. 78 No. 2 August 1986, pp. 376-377
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Vitamin E Problems

ZVI FRIEDMAN MD, FRCP(C)1

1 Department of Pediatrics, Baylor College of Medicine, 1919 La Branch, Houston, TX 77002

To the Editor.—

I read with great interest the commentary by J. A. Lemons and M. J. Maisels on vitamin E.1 The timing for such a critical review of the subject could not be more appropriate because vitamin E is now being prescribed widely and in large doses to very low birth weight infants. I have two basic comments to the report by Lemons and Maisels.

First, the authors reported their experience with the oral administration of vitamin E and pointed out that serum levels are frequently elevated following the oral administration of 100 mg/kg of vitamin E. Thirty-eight percent of their patients had serum levels greater than 3.5 mg/dL, whereas 13% exceeded 5.5 mg/dL.