PEDIATRICS Vol. 78 No. 2 August 1986, pp. 298-304
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Hypercalciuria, Hyperphosphaturia, and Growth Retardation in Children With Diabetes Mellitus

John I. Malone MD1, Saul Lowitt PhD1, John A. Duncan MD1, Shirish C. Shah MD1, Alfonso Vargas MD1, and Allen W. Root MD1

1 From the Department of Pediatrics and The Diabetes Center, University of South Florida College of Medicine, Tampa

The role of hypercalciuria and hyperphosphaturia in the growth retardation of children with diabetes mellitus was investigated in 157 children with diabetes whose mean height was less than that of 37 nondiabetic siblings of similar age (P < .025). Hyperglycemia, hypercalciuria, and hyperphosphaturia were assessed coincident with the height measurement of each child in a cross-sectional suvey. The distribution of height percentiles of the children with diabetes was skewed to the left with 61% at or below the 50th percentile. Eleven percent of the insulin-dependent children with diabetes mellitus were shorter than would be anticipated by a normal distribution of the 157 children. The duration of diabetes (hyperglycemia) had the greatest influence upon the children's height. Children with diabetes were shorter than the nondiabetic subjects by the fourth year of hyperglycemia, and this difference in height became statistically significant after 7 years or more of diabetes. The degree of hypercalciuria and hyperphosphaturia was more closely associated with reduced height in children with diabetes than was the degree of hyperglycemia, although the renal wastage of calcium and phosphorus seemed to be the result of glucosuria. Because hypercalciuria and hyperphosphaturia impair growth in nondiabetic children, they may also play an important role in the poor growth of children with diabetes mellitus.

Key Words: hypercalciuria • hyperphosphaturia • growth • diabetes mellitus

Submitted on June 19, 1985
Accepted on November 18, 1985




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