PEDIATRICS Vol. 78 No. 1 July 1986, pp. 21-25
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Sequelae of Acute Bacterial Meningitis in Children Treated for Seven Days

T. Jadavji MD1, W. D. Biggar MD1, R. Gold MD1, and C. G. Prober MD1

1 From the Division of Infectious Disease, The Hospital for Sick Children, and the Department of Pediatrics, University of Toronto, Faculty of Medicine, Toronto

The sequelae of acute bacterial meningitis in children who were treated with ampicillin or chloramphenicol for seven days during the period January 1979 to June 1983 were assessed prospectively. The 235 patients (117 boys and 118 girls) ranged in age from four days to 18 years (mean 26.4 months). Haemophilus influenzae type b was isolated in 70% of patients, Streptococcus pneumoniae in 20%, and Neisseria meningitidis in 10%. The mortality rate was 6.4%. No relapses occurred. Of the 220 survivors, 171 had neurologic psychometric, audiologic, and ophthalmologic assessments performed for a minimum of 1 year following their illness. One hundred thirty-six (80%) children had no detectable sequelae; 20% had mild to severe handicaps. The frequency of sequelae was greatest among children with S pneumoniae meningitis (57%) and least among children with N meningitidis (0%). The sequelae observed included: sensorineural hearing loss (12.9%), developmental delay (5.3%), speech defect (4.7%), motor defect (3.0%), hydrocephalus (1.7%), and seizure disorder (1%). The frequency of observed sequelae among these patients is similar to that previously reported in children treated for ten to 14 days. Our findings indicate that seven days of intravenous antibiotic therapy is adequate for the treatment of bacterial meningitis in children.

Key Words: bacterial meningitis • neurologic sequelae • antibiotic

Submitted on August 27, 1985
Accepted on October 7, 1985




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