PEDIATRICS Vol. 77 No. 6 June 1986, pp. 795-800
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wald, E. R.
Right arrow Articles by Ledesma-Medina, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wald, E. R.
Right arrow Articles by Ledesma-Medina, J.

Comparative Effectiveness of Amoxicillin and Amoxicillin-Clavulanate Potassium in Acute Paranasal Sinus Infections in Children: A Double-Blind, Placebo-Controlled Trial

Ellen R. Wald MD1, Darleen Chiponis CPNP, MEd1, and Jocyline Ledesma-Medina MD1

1 From the Departments of Pediatrics (Divisions of Infectious Disease and Ambulatory Care) and Radiology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh

This study compared the relative effectiveness of two antimicrobial preparations, amoxicillin and amoxicillin-clavulanate potassium (Augmentin), in the treatment of acute maxillary sinusitis in children 2 to 16 years of age. Of 171 children with persistent (ten to 30 days' duration) nasal discharge or daytime cough or both, 136 (80%) had abnormal maxillary sinus radiographs. These children were stratified by age and severity of symptoms and randomly assigned to receive either amoxicillin, amoxicillin-clavulanate potassium, or placebo. After the exclusion of 28 children with throat cultures positive for group A Streptococcus and 15 who did not complete their medication, the remaining 93 children were evaluated: 30 received amoxicillin, 28 received amoxicillin-clavulanate potassium, and 35 received placebo. Clinical assessment was performed at three and ten days. On each occasion, children treated with an antibiotic were more likely to be cured than children receiving placebo (P < .01 at three days, P < .05 at ten days). The overall cure rate was 67% for amoxicillin, 64% for amoxicillin-clavulanate potassium, and 43% for placebo.

Key Words: acute sinusitis • respiratory infection • antimicrobial treatment • amoxicillin • amoxicillinclavukinate potassium

Submitted on July 29, 1985
Accepted on August 29, 1985




This article has been cited by other articles:


Home page
 AAP Grand RoundsHome page
M. W. Weinberger
Additional Evidence Antibiotics Are Not Helpful for Sinusitis
AAP Grand Rounds, April 1, 2008; 19(4): 37 - 38.
[Full Text] [PDF]

Home page
 Ann Fam MedHome page
A. De Sutter, M. Lemiengre, G. Van Maele, M. van Driel, M. De Meyere, T. Christiaens, and J. De Maeseneer
Predicting Prognosis and Effect of Antibiotic Treatment in Rhinosinusitis
Ann. Fam. Med, November 1, 2006; 4(6): 486 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
D. R. Nash, J. Harman, E. R. Wald, and K. J. Kelleher
Antibiotic Prescribing by Primary Care Physicians for Children With Upper Respiratory Tract Infections
Arch Pediatr Adolesc Med, November 1, 2002; 156(11): 1114 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. Kahn, J. G. Frohna, and E. R. Wald
'Sinusitis'?
Pediatrics, July 1, 2002; 110(1): 192 - 193.
[Full Text] [PDF]

Home page
 AAP NewsHome page
L. O'Keefe
AAP guideline: Note history before prescribing antibiotics for sinusitis
AAP News, September 1, 2001; 19(3): 115 - 115.
[Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
F. M. Baroody
Pediatric Sinusitis
Arch Otolaryngol Head Neck Surg, September 1, 2001; 127(9): 1099 - 1101.
[Full Text] [PDF]

Home page
 PediatricsHome page
Subcommittee on Management of Sinusitis and Commit
Clinical Practice Guideline: Management of Sinusitis
Pediatrics, September 1, 2001; 108(3): 798 - 808.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. P. A. Ioannidis and J. Lau
Technical Report: Evidence for the Diagnosis and Treatment of Acute Uncomplicated Sinusitis in Children: A Systematic Overview
Pediatrics, September 1, 2001; 108(3): e57 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Pediatr. Rev.Home page
D. Nash
Point-Counterpoint: Sinusitis
Pediatr. Rev., September 1, 2001; 22(9): 291 - 292.
[Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
M. H. Rathore
Are Antimicrobials Useful in the Treatment of Acute, Uncomplicated Sinusitis in Children?
AAP Grand Rounds, July 1, 2001; 6(1): 2 - 3.
[Full Text] [PDF]

Home page
 PediatricsHome page
J. M. Garbutt, M. Goldstein, E. Gellman, W. Shannon, and B. Littenberg
A Randomized, Placebo-Controlled Trial of Antimicrobial Treatment for Children With Clinically Diagnosed Acute Sinusitis
Pediatrics, April 1, 2001; 107(4): 619 - 625.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
M. W. Simon
Treatment of Acute Sinusitis in Childhood with Ceftibuten
Clinical Pediatrics, June 1, 1999; 38(5): 269 - 272.
[Abstract] [PDF]

Home page
 BMJHome page
S. D de Ferranti, J. P A Ioannidis, J. Lau, W. V Anninger, and M. Barza
Are amoxycillin and folate inhibitors as effective as other antibiotics for acute sinusitis? A meta-analysis
BMJ, September 5, 1998; 317(7159): 632 - 637.
[Abstract] [Full Text]

Home page
 Arch Pediatr Adolesc MedHome page
M. Aitken and J. A. Taylor
Prevalence of Clinical Sinusitis in Young Children Followed Up by Primary Care Pediatricians
Arch Pediatr Adolesc Med, March 1, 1998; 152(3): 244 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
P. A. R. Clement, C. D. Bluestone, F. Gordts, R. P. Lusk, F. W. A. Otten, H. Goossens, G. K. Scadding, H. Takahashi, F. L. van Buchem, P. Van Cauwenberge, et al.
Management of Rhinosinusitis in Children: Consensus Meeting, Brussels, Belgium, September 13, 1996
Arch Otolaryngol Head Neck Surg, January 1, 1998; 124(1): 31 - 34.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. L. O'Brien, S. F. Dowell, B. Schwartz, S. M. Marcy, W. R. Phillips, and M. A. Gerber
Acute Sinusitis---Principles of Judicious Use of Antimicrobial Agents
Pediatrics, January 1, 1998; 101(1): 174 - 177.
[Abstract] [Full Text] [PDF]

Home page
 DTBHome page
Augmentin reconsidered
DTB, October 1, 1996; 34(10): 76 - 78.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
M. Lindbaek, P. Hjortdahl, and U. L-H Johnsen
Randomised, double blind, placebo controlled trial of penicillin V and amoxycillin in treatment of acute sinus infections in adults
BMJ, August 10, 1996; 313(7053): 325 - 329.
[Abstract] [Full Text]

Home page
 CLIN PEDIATRHome page
W. Richards, R. M. Roth, and J. A. Church
Underdiagnosis and Undertreatment of Chronic Sinusitis in Children
Clinical Pediatrics, February 1, 1991; 30(2): 88 - 92.
[Abstract] [PDF]