PEDIATRICS Vol. 77 No. 5 May 1986, pp. 783-784
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Intramuscular Penicillin

MICHAEL. R. WEIR MC, USA1

1 Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, Texas 79920-5001

To the Editor.—

Stollers and Losey's report of vascular damage with intramuscular benzathine penicillin argues that the delivery system obscures the safeguard against intravascular injection,1 an argument made previously but less colorfully.2 The millions of doses used worldwide attest to the efficacy of persistent low penicillin blood levels in therapy and prophylaxis. The occasional reports of vascular complications including avascular necrosis of the gluteal region, the perineum, and the ipsilateral or contralateral foot, sciatic nerve palsy, and transverse myelopathy raise questions about safety as well as mechanisms of injury.




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M. R. Weir
Intravascular Injuries from Intramuscular Penicillin
Clinical Pediatrics, February 1, 1988; 27(2): 85 - 90.
[Abstract] [PDF]