PEDIATRICS Vol. 77 No. 5 May 1986, pp. 779-781
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Prevention of Intraventricular Hemorrhage With Phenobarbital Therapy: Now What?

STEVEN M. DONN MD1, GARY W. GOLDSTEIN MD1, and DIETRICH W. ROLOFF MD1

1 Departments of Pediatrics and Neurology, University of Michigan Medical Center, Ann Arbor

In the April issue of Pediatrics, Kuban and colleagues1 report on what is now the largest trial of phenobarbital administration to prevent neonatal intraventricular hemorrhage. They randomized 280 ventilator-dependent preterm infants weighing less than 1,751 g at birth. Three affiliated intensive care nurseries collaborated during a 3-year period to enroll a sample size determined by a prospective statistical analysis to test a predicted reduction of intraventricular hemorrhage by 50% in treated patients. Infants were entered into the trial only if they were receiving assisted ventilation before 12 hours of age and had no evidence of intraventricular hemorrhage by sonographic examination. This clinical trial was well designed and carefully run.




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 J Child NeurolHome page
W. C. Allan
Intraventricular Hemorrhage
J Child Neurol, January 1, 1989; 4(1_suppl): S12 - S22.
[Abstract] [PDF]