PEDIATRICS Vol. 77 No. 4 April 1986, pp. 465-470
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Twenty Years of Renal Transplantation in Children

Donald Potter MD1, Nicholas Feduska MD1, Juliet Melzer MD1, Marvin Garovoy MD1, Susan Hopper MSN1, Robert Duca MBA1, and Oscar Salvatierra Jr MD1

1 From the Departments of Pediatrics and Surgery, University of California, San Francisco

Two-hundred three children 1 to 16 years of age received kidney transplants during a 20-year period, 100 from living donors and 103 from cadaver donors. The overall survival rate was 79%. Actuarial patient and kidney survival rates at 15 years were 79% and 52%, respectively, for recipients of living donor kidneys and 57% and 19%, respectively, for recipients of cadaver donor kidneys. One of two children who received transplants in 1964 was alive 20frac12 years later. Twenty-nine children had kidneys that had functioned more than 10 years; their mean serum creatinine concentration was 1.7 mg/dL and 24 were fully rehabilitated. Eighteen were more than 2 SD below the mean height of normal chidren, however. Comparison of survival rates during successive 5-year intervals showed significant improvement in patient survival during the 20-year period and smaller improvements in kidney survival after 1979. Patient survival after living donor transplants during the last 10 years was 100%, and kidney survival during the last 5 years was 92%. Improvement was attributed to the effect of experience, as well as to changes in immunosuppressive therapy in 1972 and the introduction of donor-specific transfusions in 1978.

Key Words: renal transplantation • rehabilitation

Submitted on May 24, 1985
Accepted on July 12, 1985


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S. M. Mauer, A. Caplan, T. E. Nevins, and J. S. Najarian
Renal Transplantation for Children
JAMA, July 21, 1989; 262(3): 348 - 348.
[Abstract] [PDF]