PEDIATRICS Vol. 77 No. 2 February 1986, pp. 173-178
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Albuterol Protects Against Exercise-Induced Asthma Longer Than Metaproterenol Sulfate

Robert Berkowitz MD1, Eugene Schwartz MD1, Don Bukstein MD1, Michael Grunstein MD, PhD1, and Hyman Chai MD1

1 From the National Jewish Hospital and Research Center/National Asthma Center, Denver

Both metaproterenol sulfate and albuterol are inhaled medications commonly used to prevent exercise-induced bronchospasm. Their efficacy and duration of action in controlling exercise-induced bronchospasm were compared with placebo in 18 asthmatic children (age range: 12 to 17 years) in a single-blind randomized crossover study. Standardized treadmill exercise challenges were repeated every two hours for up to six hours following the initial exercise test. With the initial exercise challenge, both active medications blocked exercise-induced bronchospasm with equal efficacy. On the other hand, when the duration of action of the medications was compared: (1) albuterol blocked exercise-induced bronchospasm longer than metaproterenol sulfate in eight subjects, (2) the reverse was true in only one patient, and (3) the medications blocked for equal duration in nine subjects. Thus, although both active agents were equally efficacious in blocking exercise-induced bronchospasm initially, the duration of action of albuterol was significantly (P < .05) longer on serial testing than that of metaproterenol sulfate. Both medications were significantly better than placebo in efficacy and duration of action.

Key Words: albuterol • metaproterenol sulfate • exercise-induced bronchospasm

Submitted on April 22, 1985
Accepted on November 21, 1985


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