PEDIATRICS Vol. 77 No. 2 February 1986, pp. 152-157
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Outbreak of Cryptosporidiosis in a Day-Care Center

Gershon Alpert MD1, Louis M. Bell MD1, Carl E. Kirkpatrick PhD, VMD1, Lawrence D. Budnick MD1, Joseph M. Campos PhD1, Harvey M. Friedman MD1, and Stanley A. Plotkin MD1

1 From the Divisions of Infectious Diseases and Microbiology, Children's Hospital of Philadelphia, University of Pennsylvania, School of Medicine and School of Veterinary Medicine, and the Philadelphia Department of Public Health, Philadelphia

An outbreak of diarrhea due to infection with Cryptosporidium occurred in a day-care center. During a period of 2 months, 23 of 53 (43%) children attending the day-care center and 15 of 104 (14%) household contacts had diarrhea. Cryptosporidium oocysts were identified in 13 of 20 (65%) symptomatic children tested compared with three of 27 (11%) asymptomatic children (khgr2 = 12.56, P < .001). Enteropathogenic bacteria, enteroviruses, rotavirus, and other protozoan parasites were ruled out as the cause of the diarrhea. A history of diarrhea in household contacts was associated with excretion of Cryptosporidium oocysts by the children. Human-to-human transmission of the infection was suggested by the epidemiology.

Key Words: Cryptosporidium • day-care center • diarrhea

Submitted on February 25, 1985
Accepted on April 24, 1985


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