PEDIATRICS Vol. 77 No. 1 January 1986, pp. 136-137
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Nutrition Study Design Questioned

LYNN MARIE JANAS MD1, MARY FRANCES PICCIANO PhD1, and TERRY F. HATCH MD1

1 Division of Nutritional Sciences, Department of Foods and Nutrition, University of Illinois, Urbana, IL 61801

In Reply.—

We welcome the interest in our study1 and are pleased to have the opportunity to respond to Dr Wilson's letter. At the initiation of our study, there were two equivocal reports on indices of protein metabolism in full-term infants fed human milk, whey-predominant formula, or cow's milk formula.2-4 Therefore, our objective was to assess whether specific parameters of protein metabolism responded quantitatively to dietary intakes of protein, nitrogen, and amino acids. Our results did confirm that plasma aminograms are elevated with feeding either a whey-predominant or a cow's milk formula3; however, we are the first to report that total protein (total nitrogen) intake is as important as protein quality in determining plasma amino acid response in infants.