PEDIATRICS Vol. 77 No. 1 January 1986, pp. 130-131
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GARIN, E. H.
Right arrow Articles by RICHARD, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GARIN, E. H.
Right arrow Articles by RICHARD, G. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Metolazone and Furosemide Therapy for Edema

EDUARDO H. GARIN MD1 and GEORGE A. RICHARD MD1

1 Pediatric Department, University of Florida, Gainesville, FL 32601

To the Editor.—

In his report, Dr Arnold1 concludes that the combination of furosemide and metolazone offers a useful and effective oral therapy in most children with edema resistant to furosemide. In our opinion, pitfalls in patient selection and methodology cast doubts on his conclusions.

Dr Arnold defines furosemide resistance as no clinical response after a dose of 2 to 4 mg/kg/d of furosemide. However, the inclusion of patients who did not respond to 2 mg/kg/d seems inappropriate because: (1) 2 mg/kg/d has been considered the initial dose to treat these types of patients2 and (2) some of these patients may have responded to higher doses of furosemide (3 or 4mg/kg/d).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?