PEDIATRICS Vol. 76 No. 6 December 1985, pp. 901-904
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Routine Quantitative Blood Cultures in Children With Haemophilus influenzae or Streptococcus pneumoniae Bacteremia

Louis M. Bell MD1, Gershon Alpert MD1, Joseph M. Campos PhD1, and Stanley A. Plotkin MD1

1 From the Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia

The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with ge100 colony-forming units per milliliter were significantly more likely to have meningitis (P < .01, khgr2 = 7.5). On the other hand, all patients with S. pneumoniae bacteremia with colony counts lower than 15 colony-forming units per milliliter had "occult bacteremia" with no focus of infection. The data suggest that patients with higher levels of bacteremia have more severe disease. Quantitative blood culture results may be helpful in identifying which children are at risk for invasive disease.

Key Words: quantitative blood culture • occult bacteremia • Haemophilus influenzae • Streptococcus pneumoniae • meningitis

Submitted on November 5, 1984
Accepted on January 28, 1985




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