PEDIATRICS Vol. 76 No. 5 November 1985, pp. 857
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Vitamin E and Complement

BERNARD RUDENSKY PhD1, MEYER ISACSOHN MD1, and ARTHUR I. EIDELMAN MD1

1 Departments and of Microbiology, Infectious Diseases, and Neonatology, Shaare Zedek Medical Center

To the Editor.—

The pros and cons of vitamin E therapy for premature infants have been quite extensively written about during the past year, especially in Pediatrics.1-4 We were interested in the report of Johnson et al,5 showing increased incidence of sepsis and necrotizing enterocolitis in neonates with elevated serum vitamin E levels. Major et a16 reported that vitamin A inhibited complement-induced hemolysis of sensitized erythrocytes, at concentrations similar to those for vitamin E, implicated by Johnson et al as resulting in increased sepsis rates.