PEDIATRICS Vol. 76 No. 5 November 1985, pp. 849-851
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WARE, J. H.
Right arrow Articles by EPSTEIN, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WARE, J. H.
Right arrow Articles by EPSTEIN, M. F.

Extracorporeal Circulation in Neonatal Respiratory Failure: A Prospective Randomized Study

JAMES H. WARE PhD1 and MICHAEL F. EPSTEIN MD2

1 Department of Biostatistics, Harvard School of Public Health
2 Department of Pediatrics, Harvard Medical School, The Children's Hospital

Bartlett et al,1 in last month's issue of Pediatrics, report the results of an innovative clinical trial of extracorporeal membrane oxygenation (ECMO) in the treatment of infants with respiratory failure. The authors report that, prior to introducing ECMO, infants meeting their criteria for respiratory failure had an 80% or greater chance of early death despite optimal conventional care. Because continued randomization in a 50-50 fashion would have presented ethical problems if early results were very favorable to ECMO, the investigators employed an "adaptive allocation" scheme, that is, a design that modified the treatment assignment probabilities according to results for previously randomized patients. The design chosen was a "randomized play-the-winner" design.2




This article has been cited by other articles:


Home page
 Br J Philos SciHome page
J. Worrall
Why There's No Cause to Randomize
Brit J Philos Sci, September 1, 2007; 58(3): 451 - 488.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
R. H. Bartlett
Historical Perspectives: Extracorporeal Membrane Oxygenation (ECMO)
NeoReviews, June 1, 2005; 6(6): e251 - e254.
[Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
A. Biswas
Adaptive designs for binary treatment responses in phase III clinical trials: controversies and progress
Statistical Methods in Medical Research, October 1, 2001; 10(5): 353 - 364.
[Abstract] [PDF]