PEDIATRICS Vol. 76 No. 5 November 1985, pp. 814-817
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moss, R. B.
Right arrow Articles by Weibel, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moss, R. B.
Right arrow Articles by Weibel, A.

Cystic Fibrosis and Neuroblastoma

Richard B. Moss MD1, Joann Blessing-Moore MD1, S. W. Bender MD1, and A. Weibel MD1

1 From the Department of Pediatrics, Stanford University Medical School, Palo Alto, California, and Department of Pediatrics I, Center of Pediatrics, Johann Wolfgang Goethe University, Frankfurt, Federal Republic of Germany

Two cases of coexistent cystic fibrosis and infantile thoracic neuroblastoma are presented. In one patient, neuroblastoma was congenital, and diagnosis of cystic fibrosis was made at 3 months of age; in the other, the diagnosis of cystic fibrosis was made at 7 months of age, preceding that of neuroblastoma by 4 months. In both infants, surgical resection of the tumors have been successful. Recent advances in the genetic aspects of neuroblastoma, including translocation and activation of the oncogene N-myc, are discussed. Current recombinant DNA technology, which can identify translocation of N-myc and allow localization of the cystic fibrosis gene if the translocation occurs near the cystic fibrosis allele, is being applied to these cases.

Key Words: cystic fibrosis • neuroblastoma • oncogene

Accepted on December 12, 1984




This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
P. Maisonneuve, S. C. FitzSimmons, J. P. Neglia, P. W. Campbell III, and A. B. Lowenfels
Cancer Risk in Nontransplanted and Transplanted Cystic Fibrosis Patients: A 10-Year Study
J Natl Cancer Inst, March 5, 2003; 95(5): 381 - 387.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. P. Neglia, S. C. FitzSimmons, P. Maisonneuve, M. H. Schoni, F. Schoni-Affolter, M. Corey, A. B. Lowenfels, and The Cystic Fibrosis and Cancer Study Group
The Risk of Cancer among Patients with Cystic Fibrosis
N. Engl. J. Med., February 23, 1995; 332(8): 494 - 499.
[Abstract] [Full Text] [PDF]