PEDIATRICS Vol. 76 No. 4 October 1985, pp. 508-511
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stegagno, M.
Right arrow Articles by DE Luca, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stegagno, M.
Right arrow Articles by DE Luca, E. C.

Immunologic Follow-up of Infants Treated With Granulocyte Transfusion for Neonatal Sepsis

Michele Stegagno MD1, Roberto Pascone BS1, Patrizia Colarizi MD1, Francesco Laurenti MD1, Giancarlo Isacchi MD1, Giovanni Bucci MD1, and Erminia Carapella DE Luca MD1

1 From the Institutes of Child Health, Pediatrics, and Hematology, Università "La Sapienza," Rome

The immunologic status and the occurrence of alloimmunization against granulocytes, platelets, lymphocytes, and red cells was evaluated in 33 babies who received granulocyte transfusion because of neonatal sepsis. Nine age-matched babies were examined as control. A first group of 19 infants was examined only once between 6 and 23 months of age. Alloantibodies were searched by the following serologic methods: standard techniques for red cell antibodies; lymphocytotoxicity test; agglutination and immunofluorescence tests on granulocytes and platelets. No antibodies were demonstrated. The immunologic profile was investigated by determining the Ig levels, the percentage of E rosetteforming cells, and the lymphocyte blastic response to phytohemagglutinin and concanavalin A. Granulocyte function was studied by phagocytosis and killing of Candida. No significant differences were observed between treated and control babies. In a second group of 14 infants the occurrence of early immunization within 3 to 9 weeks after the last transfusion was investigated. No evidence of early immunization was found. The present data suggest that following neonatal granulocyte transfusion the risk of adverse immune reactions should be low.

Key Words: neonatal sepsis • granulocyte transfusion • immunologic follow-up • alloimmunization

Submitted on July 22, 1984
Accepted on December 27, 1984




This article has been cited by other articles:


Home page
 J Intensive Care MedHome page
T. E. Harper and R. D. Christensen
Bacterial Sepsis in the Newborn Infant: Developmental Deficiencies in Neutrophils and the Role of Neutrophil Transfusion
J Intensive Care Med, September 1, 1987; 2(5): 279 - 291.
[Abstract] [PDF]