PEDIATRICS Vol. 76 No. 3 September 1985, pp. 420-424
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edwards, K. M.
Right arrow Articles by Wright, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edwards, K. M.
Right arrow Articles by Wright, P. F.

Adenovirus Infections in Young Children

Kathryn M. Edwards MD1, Juliette Thompson RN1, Janet Paolini BS1, and Peter F. Wright MD1

1 From the Department of Pediatrics, Vanderbilt University School of Medicine, Nashville

The importance of adenovirus in initiating respiratory disease in young children is stressed in this report. The incidence, clinical illness, asymptomatic carriage, and serologic response of acute adenovirus-associated infection are described in a carefully followed cohort of normal children cultured with each episode of febrile respiratory illness. During a 6-year period, 8.2% of 1,416 nasal washings obtained from sick infants and children less than 7 years of age yielded adenovirus. Adenoviruses were isolated from only 1/174 (0.6%) cultures taken from well children. Typing of 98 isolates showed 81% to be types 1 or 2. A ge fourfold rise in neutralizing titer was seen in 45/59 (76%) sampled. In a subset of the cohort observed for 2-week periods in a day care setting, 14 of 21 well children (67%) exposed to symptomatic children with adenovirus infection developed febrile respiratory symptoms and shedding of the same serotype within 2 weeks of exposure. This study confirms that adenovirus has a high attack rate and causes significant respiratory disease in young children.

Key Words: adenovirus • respiratory infections

Accepted on December 14, 1984




This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
L. B. Blyn, T. A. Hall, B. Libby, R. Ranken, R. Sampath, K. Rudnick, E. Moradi, A. Desai, D. Metzgar, K. L. Russell, et al.
Rapid Detection and Molecular Serotyping of Adenovirus by Use of PCR Followed by Electrospray Ionization Mass Spectrometry
J. Clin. Microbiol., February 1, 2008; 46(2): 644 - 651.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. J. Pelletier, J. M. Mansbach, and C. A. Camargo Jr
Direct Medical Costs of Bronchiolitis Hospitalizations in the United States
Pediatrics, December 1, 2006; 118(6): 2418 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Jogler, D. Hoffmann, D. Theegarten, T. Grunwald, K. Uberla, and O. Wildner
Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species.
J. Virol., April 1, 2006; 80(7): 3549 - 3558.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. Echavarria, D. Maldonado, G. Elbert, C. Videla, R. Rappaport, and G. Carballal
Use of PCR To Demonstrate Presence of Adenovirus Species B, C, or F as Well as Coinfection with Two Adenovirus Species in Children with Flu-Like Symptoms
J. Clin. Microbiol., February 1, 2006; 44(2): 625 - 627.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. V. Williams, P. A. Harris, S. J. Tollefson, L. L. Halburnt-Rush, J. M. Pingsterhaus, K. M. Edwards, P. F. Wright, and J. E. Crowe Jr.
Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children
N. Engl. J. Med., January 29, 2004; 350(5): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
C. Rocholl, K. Gerber, J. Daly, A. T. Pavia, and C. L. Byington
Adenoviral Infections in Children: The Impact of Rapid Diagnosis
Pediatrics, January 1, 2004; 113(1): e51 - 56.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. T. Garnett, D. Erdman, W. Xu, and L. R. Gooding
Prevalence and Quantitation of Species C Adenovirus DNA in Human Mucosal Lymphocytes
J. Virol., October 2, 2002; 76(21): 10608 - 10616.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. J. Gavin and B. Z. Katz
Intravenous Ribavirin Treatment for Severe Adenovirus Disease in Immunocompromised Children
Pediatrics, July 1, 2002; 110(1): e9 - 9.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Hayashi
Latent Adenovirus Infection in COPD*
Chest, May 1, 2002; 121(5_suppl): 183S - 187S.
[Abstract] [Full Text] [PDF]