PEDIATRICS Vol. 76 No. 2 August 1985, pp. 327-329
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Questions on the Vitamin E Study

MICHAEL E. SPEER MD1, ARNOLD J. RUDOLPH MD1, and HELEN M. HITTNER MD1

1 Departments of Pediatrics and Ophthalmology, Baylor College of Medicine, Houston, TX 77030

In Reply.—

Regarding the efficacy of a few early intramuscular injections of vitamin E to decrease the incidence and severity of intraventricular hemorrhage reported by Speer et al,1 Jansen adds his concerns to those already expressed in the commentary by Phelps.2

The intraventricular hemorrhage data were a retrospective study, the inborn and outborn infants were not randomly separated into control and treatment groups, and the small numbers resulted in some nonsignificant differences between control infants and treated infants.