PEDIATRICS Vol. 76 No. 2 August 1985, pp. 286-288
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Healing Rates of Treated and Untreated Bone Lesions in Histiocytosis X

Richard B. Womer MD1, R. Beverly Raney Jr MD1, and Giulio J. D'Angio MD1

1 From the Children's Cancer Research Center and Division of Oncology, Children's Hospital of Philadelphia, Philadelphia

Evaluation of the response of histiocytosis khgr to various forms of treatment is difficult, because presentation patterns are protean and the disease can be self-limited. A retrospective evaluation was made of the healing of 42 histiocytosis khgr bone lesions, in 21 patients treated in variety of ways, using serial radiographs and a semiquantitative scoring system. Treatments included various combinations of surgery (simple biopsy or curettage), radiotherapy (200 to 1,200 centi-Gray [cGy]), chemotherapy (according to various protocols), and local steroid injection. Median times to a given degree of healing were similar across treatment groups and in untreated lesions. It was concluded that mode of treatment does not exert a strong influence on the rate of healing of histiocytosis khgr bone lesions. Some healing should be apparent 4 months after diagnosis, but complete healing may take many months. Treatment of histiocytosis khgr bone lesions is indicated only if intense pain or risk of fracture or deformity are present.

Key Words: histiocytosis khgr • eosinophilic granuloma • bone tumors (benign)

Submitted on April 25, 1984
Accepted on August 28, 1984




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