PEDIATRICS Vol. 76 No. 2 August 1985, pp. 159-166
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Oral Rehydration Therapy for Acute Diarrhea in Ambulatory Children in the United States: A Double-Blind Comparison of Four Different Solutions

Mathuram Santosham MD, MPH1, Barbara Burns PNP, MPH1, Vinay Nadkarni BS1, Stephan Foster Pharm D1, Steven Garrett RPh1, Larry Croll RPh1, J. Crosson O'Donovan MD1, Radha Pathak MD1, and R. Bradley Sack MD, ScD1

1 From the Division of Geographic Medicine and Eudowood Division of Pediatric Infectious Diseases, The Johns Hopkins University School of Medicine; Departments of Pediatrics and Medicine, Francis Scott Key Medical Center (formerly Baltimore City Hospital) and The Johns Hopkins University School of Medicine, Baltimore, and US Public Health Service Indian Hospital, Whiteriver, Arizona

Oral rehydration solutions containing 50 to 90 mmol/L of sodium have recently been recommended for the treatment of diarrhea in both hospitalized and ambulatory children in the United States. Few data are available, however, from ambulatory US children. Therefore, we conducted a randomized double-blind study comparing the use of four different oral rehydration solutions with differing concentrations of sodium, glucose, and base. Ambulatory children less than 2 years of age with acute diarrhea (N = 140) were randomly chosen to receive solutions containing sodium at 90 (solution A), 50 (solution B), and 30 mmol/L (solutions C and D). All oral rehydration solutions contained 20 g/L of glucose except solution D which contained 50 g/L of glucose. Solution A contained bicarbonate as its base source whereas the other three contained citrate. All but three (98%) children were treated uneventfully according to the study protocol, and there were no differences among groups in measurements of clinical outcome. It was concluded that in ambulatory US children, oral rehydration solutions containing 90, 50, or 30 mmol/L of sodium can be used safely for the treatment of mild acute diarrhea and that citrate is as efficacious as bicarbonate in the correction of acidosis.

Key Words: oral rehydration solutions • oral rehydration • diarrhea • dehydration

Submitted on June 6, 1984
Accepted on October 2, 1984




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