PEDIATRICS Vol. 76 No. 1 July 1985, pp. 64-68
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Coxsackievirus Group B Antibodies in the Ventricular Fluid of Infants with Severe Anatomic Defects in the Central Nervous System

Charles J. Gauntt PhD1, Richard J. Gudvangen MS1, Yves W. Brans MD1, and Arthur E. Marlin MD1

1 Departments of Microbiology, Pediatrics, and Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio

Ventricular fluids from four of 28 newborn infants who were initially seen with severe congenital anatomic defects in the central nervous system contained neutralizing antibody to at least one serotype of coxsackieviruses group B. Two of the four infants with anticoxsackieviruses group B antibody in the ventricular fluid did not have a detectable level of the same antibody(ies) in their serum. The ventricular fluid of one of the infants had immunoglobulin M neutralizing antibody directed against coxsackievirus B6. Of 11 mother-infant pairs that had neutralizing antibody to coxsackieviruses group B in both sera, nearly half had antibodies directed against more than one serotype. These data suggest the possibility of an association between congenital infections with coxsackieviruses group B and rare severe CNS defects.

Key Words: coxsackieviruses group B • virusneutralizing antibody • ventricular fluid • congenital hydrocephalus • hydranencephaly

Submitted on August 6, 1984
Accepted on October 19, 1984




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