PEDIATRICS Vol. 76 No. 1 July 1985, pp. 26-28
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Bacterial Etiology of Conjunctivitis-Otitis Media Syndrome

Frank F. Bodor MD1, Colin D. Marchant MD1, Paul A. Shurin MD1, and Stephen J. Barenkamp MD1

1 From the Fairview Hospital Physicians' Center, Cleveland; Department of Pediatrics, Cleveland Metropolitan General Hospital, Case Western Reserve University, Cleveland; The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, and Division of Infectious Diseases, St Louis Children's Hospital, St Louis

Simultaneous cultures of conjunctivae and middle ear exudates were obtained from 20 episodes of the syndrome of purulent conjunctivitis and otitis media. Paired cultures from 18 episodes yielded Haemophilus influenzae at both sites. In two cases with prior topical antibacterial therapy of the conjunctivitis, H influenzae was isolated from the middle ear exudate only. Biotyping and outer membrane protein analysis of H influenzae isolates from five patients demonstrated that: (1) conjunctival and middle ear strains were concordant in all cases, and (2) all five patients had different strains. The conjunctivitis-otitis media syndrome is most often caused by strains of nontypable H influenzae of diverse clonotype.

Key Words: conjunctivitis • otitis media • Haemophilus influenzae • Streptococcus pneumoniae

Submitted on May 29, 1984




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