PEDIATRICS Vol. 75 No. 6 June 1985, pp. 1048-1053
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Neonatal Hyperviscosity: Randomized Study of Effect of Partial Plasma Exchange Transfusion on Long-Term Outcome

Virginia D. Black MD1, Lula O. Lubchenco MD1, Beverly L. Koops MD1, Ronald L. Poland MD1, and Douglas P. Powell MD1

1 The Department of Pediatrics, Wayne State University, Detroit, and Department of Pediatrics, The University of Colorado Health Sciences Center and The Denver Children's Hospital, Denver

The use of partial plasma exchange transfusion in newborns with polycythemia and hyperviscosity was evaluated. Ninety-three infants with polycythemia and hyperviscosity were randomly assigned to receive either partial plasma exchange transfusion or symptomatic treatment; the infants were matched with control infants without polycythemia. Neonatal course and outcome at 1 and 2 years were evaluated for each of the three groups. Polycythemic infants had more fine motor and speech problems at 1 year of age than did control infants. At 2 years of age, polycythemic infants had more gross motor delays, neurologic diagnoses, fine motor abnormalities, and speech delays than did the control infants. There was no significant difference at 1 year between the polycythemic infants who had received partial plasma exchange transfusion and those given only symptomatic care. At 2 years, the group receiving partial plasma exchange transfusion had fewer neurologic diagnoses and fine motor abnormalities.

Key Words: polycythemia • hyperviscosity • partial plasma exchange transfusion

Submitted on December 5, 1983
Accepted on August 1, 1984




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