PEDIATRICS Vol. 75 No. 5 May 1985, pp. 908-910
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Effect of Furosemide on the Clinical Course of Transient Tachypnea of the Newborn

Thomas E. Wiswell MC1, James S. Rawlings MC1, Franklin R. Smith MC1, and Elwin D. Goo PharmD1

1 From the Neonatology Service, Department of Pediatrics, Tripler Army Medical Center Honolulu

The effect of furosemide on the course of transient tachypnea of the newborn was evaluated in a controlled, prospective study. Fifty infants with transient tachypnea of the newborn were randomly assigned to control or treatment groups. Those in the treatment group were given furosemide, 2 mg/kg orally, at the time of diagnosis followed by 1 mg/kg 12 hours later if the symptoms persisted. Infants in the control group received a placebo. Compared with infants in the control group, the furosemide-treated group demonstrated no significant difference in the duration of tachypnea nor in the length of hospitalization. It is concluded that oral furosemide, at the doses used in this study, does not significantly affect the clinical course of transient tachypnea of the newborn.

Key Words: furosemide • transient tachypnea • newborn

Submitted on May 25, 1984
Accepted on August 30, 1984