PEDIATRICS Vol. 75 No. 5 May 1985, pp. 836-843
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Glossoptosis-Apnea Syndrome in Infancy

F. Cozzi MD1 and A. Pierro MD1

1 From the Section of Pediatric Surgery, Department of Pediatrics, University of Rome, Rome

The clinical and physiologic features of 28 infants with Pierre Robin syndrome and those of 20 infants with various types of nasal obstruction were reviewed to determine whether different causes of upper airway obstructure may lead to a common syndrome. The patients had no significant differences in distribution of main clinical manifestations. Their features included cyanosis with respiratory distress, apneic spells, oropharyngeal dysphagia, vomiting, failure to thrive, cor pulmonale, brain damage, and sudden death during sleep. The common physiologic manifestation appeared to be an oropharyngeal obstruction caused by glossoptosis, which occured mainly during wakefulness. Upper airway obstruction led to hypoxemia, which, in many instances, was not associated with hypercapnia and was not relieved by oxygen administration. It is concluded that regardless of a specific cause, any airway obstruction that results in a decreased inspiratory pressure overcoming the airway maintaining genioglossus action causes a glossoptosis-apnea syndrome.

Key Words: Pierre Robin syndrome • choanal atresia • upper airway obstruction • sleep apnea syndrome • sudden infant death syndrome

Submitted on January 6, 1984
Accepted on May 15, 1984




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