PEDIATRICS Vol. 75 No. 4 April 1985, pp. 785-786
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Inadvertent Intra-arterial Injection of Penicillin: An Unseen Danger

KENNETH P. STOLLER MD1 and ROBERT LOSEY MD1

1 Department of Pediatrics, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles

The inadvertent intra-arterial injection of penicillin has been reported in the buttock1-3 and in the thigh.4,5 The resulting lesion in the small arterioles leads to thrombosis and ischemic damage to tissues supplied by them.

Schanzer et al5 felt that accidental intra-arterial injections of penicillin were the result of a design flaw in the disposable, ready-to-use containers (Tubex) in which many of the penicillin preparations are supplied. This container consists of a glass tube with a 20-gauge, 3.2-cm needle at one end and a rubber disk (plunger head) with a threaded pin inserted in it at the other. The container is positioned in a metallic or plastic injector in which a plunger is screwed to the threaded pin permitting the contents to be ejected.




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M. R. Weir
Intravascular Injuries from Intramuscular Penicillin
Clinical Pediatrics, February 1, 1988; 27(2): 85 - 90.
[Abstract] [PDF]