PEDIATRICS Vol. 75 No. 4 April 1985, pp. 770-774
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Epidemiology of Neonatal Hyperbilirubinemia

Shai Linn MD, DrPH1, Stephen C. Schoenbaum MD, MPH1, Richard R. Monson MD, DSc1, Bernard Rosner PhD1, Phillip G. Stubblefield MD1, and Kenneth J. Ryan MD1

1 From the Departments of Medicine Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Harvard Community Health Plan, and Department of Epidemiology, Harvard School of Public Health, Boston

Interview and record review data from 12,023 singleton deliveries were analyzed to determine the relationships between neonatal hyperbilirubinemia (10 mg/dL or greater) and maternal characteristics. Confounding variables were controlled by multiple logistic regression analysis. There was a statistically significant positive relationship between hyperbilirubinemia and low birth weight, Oriental race, premature rupture of membranes, breast-feeding, neonatal infection, use of the "pill" at time of conception, instrumental delivery, and history of first trimester bleeding. Maternal smoking and black race were negatively related to hyperbilirubinemia and statistically significant. In this study, other previously suspected etiologic factors such as epidural anesthesia, parity, use of oxytocin in labor, and white race were not associated with hyperbilirubinemia.

Key Words: neonatal hyperbilirubinemia • low-birth-weight infants • breast-feedings • smoking in pregnancy

Submitted on April 18, 1984
Accepted on July 25, 1984




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