PEDIATRICS Vol. 75 No. 4 April 1985, pp. 709-713
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Aminophylline Versus Doxapram in Idiopathic Apnea of Prematurity: A Double-Blind Controlled Study

Fabian Eyal MD1, Gad Alpan MD1, Ephraim Sagi MD1, Benjamin Glick MD1, Ofra Peleg MD1, Yaron Dgani MD1, and Ilan Arad MD1

1 From the Neonatal Intensive Care Unit, Department of Pediatrics, Hadassah University Hospital-Mt Scopus, Jerusalem

A double-blind controlled study, in two parts, was undertaken to compare the effectiveness of aminophylline and doxapram therapy in idiopathic apnea of prematurity. In the first part of this study, eight of 15 infants responded to doxapram therapy with complete cessation of apneic spells and six of 11 infants responded similarly to administration of aminophylline. These differences were statistically insignificant. In the second part of the study, assessment was made of whether the addition of doxapram to aminophylline therapy was effective in treatment of apnea of prematurity that had been unresponsive to aminophylline alone. Of ten infants who continued to have apneic spells during treatment with aminophylline, eight responded to the addition of doxapram with complete cessation of apnea. Nine infants received placebo in addition to aminophylline, and none had a reduction in frequency of apnea.

Key Words: aminophylline • doxapram • apnea of prematurity

Submitted on April 19, 1984