PEDIATRICS Vol. 75 No. 3 March 1985, pp. 615
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Bronchiolitis and Recurrent Wheezing

KENNETH M. MCCONNOCHIE MD1 and KLAUS J. ROGHMANN PHD1

1 Department of Pediatrics, Rochester General Hospital, 1425 Portland Ave, Rochester, NY 14621

In Reply.—

We appreciate the comments of Welliver regarding our recent article. His primary concerns relate to the issue of causality, particularly the methodology of establishing a causal relationship.

These concerns are addressed in our article (Pediatrics 1984;74:1-10) as follows:

Although a historical cohort study cannot, by its nature, prove causality, this study's findings are consistent with the hypothesis that bronchiolitis is a causal factor in wheezing. One may speculate that there is a latent factor accounting for the observed bronchiolitis-wheezing association (possibly a genetic factor common both to children who develop bronchiolitis and to children who wheeze during middle childhood years) that is measured by none of the methods employed in this study.