PEDIATRICS Vol. 75 No. 3 March 1985, pp. 598-602
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Unusual Syndrome Among Premature Infants: Association With a New Intravenous Vitamin E Product

Vichien Lorch MD1, M. Dianne Murphy MD1, Linda R. Hoersten MD1, Eva Harris RN, MPH1, Jean Fitzgerald RN1, and Sachchida N. Sinha MD1

1 From the Department of Pediatrics, University of Tennessee Memorial Research Center and Hospital, Knoxville

Eight small, premature infants developed an unusual symptom complex of pulmonary deterioration, thrombocytopenia, liver failure, ascites, and renal failure. five infants died; the health of the other three infants improved and they were discharged from the hospital. This unusual syndrome occurred after introduction of a new intravenous vitamin E product (E-Ferol, agr-tocopherol acetate) for routine use in the intensive care nursery. Even though no definite conclusion was reached as to its cause, the administration of this intravenous vitamin E product appears to be a significant risk factor.

Key Words: premature infant • vitamin E • liver failure • ascites • renal failure

Submitted on July 16, 1984
Accepted on November 20, 1984




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