PEDIATRICS Vol. 75 No. 2 February 1985, pp. 278-280
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Use of Noninvasive Tests to Predict Significant Jaundice in Full-Term Infants: Preliminary Studies

DAVID W. SMITH MBCHB(NZ)1, DOROTHY INGUILLO RN1, DARREL MARTIN RN1, HENDRIK J. VREMAN PHD1, RONALD S. COHEN MD1, and DAVID K. STEVENSON MD1

1 Department of Pediatrics, Stanford University School of Medicine, Stanford, California

Hyperbilirubinemia continues to be a common problem of the neonate. A major factor contributing to the occurrence of significant neonatal jaundice is increased bilirubin production, and in hemolytic diseases the production may exceed the normal neonatal mean by up to tenfold.1-3 However, impaired elimination of bilirubin from the body, eg, decreased conjugation or increased intestinal reabsorption, is also an important contributing factor.4

In full-term infants, the concentration of bilirubin in serum is greatest at approximately 72 hours of age,4 and significant hyperbilirubinemia occurs in approximately 5% of these neonates.5 Motivated by hospital costs and by parental requests, many pediatricians are discharging infants from the hospital before 48 hours of age.




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