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PEDIATRICS Vol. 75 No. 1 January 1985, pp. 129
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Levothyroxine Poisoning

J. DOUGLAS WHITE MD1, TOBY L. LITOVITZ MD2

1 Department of Emergency Medicine, National Capital Poison Center, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007
2 National Capital Poison Center, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007

To the Editor.—

We read the recent report by Lehrner and Weir1 of acute levothyroxine ingestions with concern. Advocacy of an aggressive approach disregards their own cases as well as the medical literature,2-5 Which contains at least seven cases of acute excessive ingestion of levothyroxine (five of which were overlooked by the authors). These reports repeatedly emphasize "a striking discrepancy between the high concentrations of active hormones and the minor clinical symptoms"4 and "the benign course after massive ingestion of levothyroxine."5


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L. K. Golightly, S. C. Smolinske, K. W. Kulig, K. M. Wruk, C. J. R. Gelman, B. H. Rumack, and C. H. Linden
Clinical Effects of Accidental Levothyroxine Ingestion in Children
Arch Pediatr Adolesc Med, September 1, 1987; 141(9): 1025 - 1027.
[Abstract] [PDF]

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 JAMAHome page
K. Kulig, L. K. Golightly, and B. H. Rumack
Levothyroxine Overdose Associated With Seizures in a Young Child
JAMA, October 18, 1985; 254(15): 2109 - 2110.
[Abstract] [PDF]