PEDIATRICS Vol. 74 No. 6 December 1984, pp. 1133
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Phenobarbital Side Effects: Hyperactivity with Speech Delay

DAVID LEVENSTEIN MD1, MARGARET E. GUTGESELL MD, MPH1, and PHYLLIS PERCY PNP1

1 Departments of Pediatrics and Community Medicine, Baylor College of Medicine, 1200 Moursund, Houston, TX 77030

To the Editor.—

Hyperactivity is a reported side effect of phenobarbital usage,1 but we are unaware of any reports of language delay accompanying the hyperactivity. We are writing to draw your attention to an interesting series of cases.

D.R. had been receiving therapeutic levels of phenobarbital for more than 2 years, because he had had two seizures before 1 year of age (the first with fever). Developmental testing after 1 year of age revealed mild mental retardation and delays in all areas.