PEDIATRICS Vol. 74 No. 6 December 1984, pp. 1065-1068
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Cord Plasma agr-Fetoprotein Values and Neonatal Jaundice

K. L. Tan MBBS, FRCPE, FRACP, DCH1, A. Loganath MSc1, A. C. Roy MSc, PhD1, H. H. Goh BSc, PhD1, S. M. Karim DSc1, and S. S. Ratnam MBBS, FRCS, FRCOG1

1 From the Departments of Pediatrics (Neonatal Unit) and Obstetrics and Gynecology, National University of Singapore, Singapore

Umbilical cord plasma agr-fetoprotein (AFP) values were determined in 127 infants with hyperbilirubinemia (56 glucose-6-phosphate dehydrogenase (G-6-PD) deficient and 71 G-6-PD normal) and 136 control subjects (73 G-6-PD deficient and 63 G-6-PD normal). The mean agr-fetoprotein value of 173 ± 35.2 (SD) mg/L for the group of infants with hyperbilirubinemia was significantly greater than that (122 ± 21.7 mg/L) for the control infants (P < .001). G-6-PD status and sex did not significantly affect the agr-fetoprotein values. Using an agr-fetoprotein level of 130 mg/L as a "cut-off" value, the incidence of false-positive results was 25.5% and the incidence of false-negative results was 11.8%. This test can be used as a screening procedure to detect infants at high risk for hyperbilirubinemia.

Key Words: neonatal jaundice • agr-fetoprotein

Submitted on August 23, 1983
Accepted on February 14, 1984