PEDIATRICS Vol. 74 No. 5 November 1984, pp. 872-875
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arnold, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arnold, W. C.

Efficacy of Metolazone and Furosemide in Children with Furosemide-Resistant Edema

Watson C. Arnold MD1

1 From the Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital, Little Rock

The effect of a combination of metolazone (0.2 to 0.4 mg/kg/d) and furosemide (2 to 4 mg/kg/d) in achieving a natriuresis and diuresis was measured in 14 children during 22 episodes of edema resistant to furosemide alone. Urinary volume increased from 24 ± 14 mL/kg/d for patients receiving furosemide to 51 mL/kg/d with combined diuretic therapy (P < .01), and sodium excretion increased from 34 ± 5 mEq/d to 155 ± 176 mEq/d (P < .01). Two children with severe hypoalbuminemia (serum albumin level <1.5 g/dL) and normal renal function, and five children with chronic renal insufficiency (71%) did not respond to combined diuretic therapy. The combination of furosemide and metolazone offers a useful and effective oral therapy in most children with edema resistant to furosemide. Children with chronic renal insufficiency and furosemide-resistant edema did not respond to combination diuretic therapy.

Key Words: nephrotic syndrome • diuretics • furosemide • metolazone • edema

Accepted on February 14, 1984




This article has been cited by other articles:


Home page
Arch. Dis. Child.Home page
M. A Lewis and A. Awan
Mannitol and frusemide in the treatment of diuretic resistant oedema in nephrotic syndrome
Arch. Dis. Child., February 1, 1999; 80(2): 184 - 185.
[Abstract] [Full Text]


Home page
NEJMHome page
M. Haas, Z. Barzilay, G. Paret, S. R. Orth, I. Rychlik, and E. Ritz
The Nephrotic Syndrome
N. Engl. J. Med., September 10, 1998; 339(11): 772 - 773.
[Full Text]